Re: Islet cells or insulinoma cells?
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Posted by Random on 23:10:49 2010/02/22
In Reply to:
Re: Islet cells or insulinoma cells? posted by Al Gordon
Great Questions
#1) It has been well shown that type 1 diabetics continue to try to regenerate their "lost" islets throughout their lives. This appears to come from metaplasia (transformation) of progenitor cells in the adult gland that can be associated with ducts or acini (Diabetologia. 2005 Nov;48(11):2221-8. Epub 2005 Oct 5.) In my humble opinion I would think that in any instance of continued metaplasia and progenitor cell differentiation the chance of cancer would increase. I do not know of any increase in pancreatic cancer in type 1 diabetics. Now is that because they die of vascular complications too soon for pancreatic cancer to develop? I don't know, but it seems that ductal transformation does not greatly increase the risk of pancreatic cancer.
Now INGAP. It stimulates/potentiates this phenomenon of duct-to-islet transformation. So does it lead to increased adenocarcinoma? Nothing that I am aware of yet, but like I said in my opinion when every you stimulate transdifferentiation there is a greater risk of cancer. Now what is that increased risk? No idea. Only something that can be answered after giving INGAP to thousands of people for tens of years to determine.
#2) In vitro in humans yes (Cell Death Differ. 2005 Jul;12(7):702-12.); In vivo in rodents yes (Ann Surg. 2004 Nov;240(5):875-84.); human in vivo not yet determined preliminary results suggestive (Cell Biochem Biophys. 2007;48(2-3):127-37.)
#3) Sorry
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