Re: What constitutes a cure?
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Posted by Al Gordon on 18:18:34 2010/01/21
In Reply to:
Re: INGAP bounced from failure to failure for 27 years posted by elliott
Good question, but I can only speak for myself. I would consider myself to be damn-near "cured" even if I had to inject a basal load of long-acting insulin each day, but had the closed-loop control of implanted islets to deal with the normal ups and downs of blood glucose throughout the day.
Naturally, there must be no systemic immunosuppression or other toxic regimens.
Even if the contribution of the implanted islets was not enough to completely eliminate injected insulin, the reduced highs and lows would be an immense improvement in quality of life. No more life-threatening hypoglycemic stupors, no body-destroying hyperglycemia, near normal HbA1c, less hour-by-hour blood testing, automatic compensation for exercise, no more "feeding the insulin", recovery of hypoglycemic awareness, and so on.
There has been negligible advances in diabetes treatment in nearly 90 years. To provide a measure of safe, redundant closed-loop control from implanted islets would be a game changer.
Al
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