Re: INGAP failed in clinical trial 8 years ago

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Posted by Elaine on 11:41:50 2010/01/19

In Reply to: Re: INGAP bounced from failure to failure for 27 years posted by Elaine

Your browser does not support inline frames, or it has been configured incorrectly. If page does not display on your browser, please <a href="http://www.healthcentral.com/diabetes/c/17/1686/ingap-revival/">CLICK HERE</a>. Diabetes - The INGAP Revival // // SEARCH_SITE = 'www.healthcentral.com/diabetes/'; MyDiabetesCentral.com Type 1 diabetes Type 2 diabetes Check a Symptom Diabetes Drug Information Top Diabetes News Doctors/Hospitals Web Resources Living With Diabetes The First 48 Hours Diabetes Diet Diabetes Treatment Diabetes Risks Tests and Results DiabeTeens: For Teens with Diabetes Create a Sharepost See All Shareposts Meet Our Community Ask a Question See All Questions Free Newsletter. Sign up now! loadMiniHomeSignedIn(); Email Password ( Forgot Password? ) Remember Me Tuesday, January, 19, 2010 Diabetes Home > SharePosts > Living With It > David Mendosa > The INGAP Revival Font size A A A Email This The INGAP Revival Related: Diabetes , Alert More Topics David Mendosa Living With It Medical Journalist Living with Diabetes and Author of Fitness and Photography for Fun, www.mendosa.com/fitnessblog After earning a B.A. with honors from the University of California,... Send Message Subscribe // David Mendosa Tuesday, May 30, 2006 View All of David Mendosa's Posts People often ask me whatever happened to INGAP Peptide, which looked like one of the most promising ways to regenerate islet cells. Until this week the news wasn’t good. In 2002 I first wrote about INGAP – islet neogenesis associated protein – in my column on the Web site of the American Diabetes Association. At that time it already has suffered one major setback, when Lilly backed out of an agreement with the licensee, GMP Companies, to commercialize it. Then, Procter & Gamble, sublicensed INGAP Peptide. But, after the Phase 2 clinical trials “did not consistently demonstrate a clinically meaningful therapeutic benefit,” P&G too gave up and returned the license to GMP Companies. Now, Kinexum Metabolics Inc ., located in Harpers Ferry, West Virginia, has sublicensed INGAP Peptide from GMP Companies for more clinical trials. Created just last year, Kinexum considers INGAP Peptide to be its “lead compound,” according to a corporate summary that Dr. G. Alexander Fleming sent me. Dr. Fleming is Kinexum’s president and CEO. Earlier he served for 12 years as the Food and Drug Administration’s senior endocrinologist and clinical group leader for the evaluation and regulation of diabetes and metabolic therapies. Dr. Fleming and his company have analyzed P&G’s Phase 2 trials and concluded that they were poorly designed. So Kinexum is going back to the drawing boards with more trials. Dr. Fleming says that he believes that INGAP Peptide “offers excellent prospects for a breakthrough therapy and the achievement of a major scientific milestone.” He told me that it will help both people with type 1 diabetes and those of us with type 2 who use insulin. “If you look at the Procter & Gamble type 2 study, you will see that there was nearly a 1 percent improvement in A1C,” he says. Developing a new diabetes drug always takes years. In this case, Dr. Aaron Vinik and Dr. Lawrence Rosenberg, then at the University of Michigan, began to investigate islet cell regeneration in 1983. Their research announcing the discovery of INGAP was reported in the May 1997 issue of the Journal of Clinical Investigation. Then came the setbacks with Lilly and P&G. The news about INGAP is a lot better now. But there is still a long way to go. Dr. Fleming believes that if the trials are successful and if the FDA agrees, INGAP Peptide could be available for commercialization in 2009. You may also enjoy these items: Screening Tests Diabetes Drug Information Top Websites View comments (6) | Add comment Font size A A A Email This Bookmark Thank you for your input Save RSS Report Abuse People who read this also read... What the community is saying... When Obesity Doesn’t Always Mean Diabetes Posted 12/29 Comments (0) When Obesity Doesn't Always Mean DiabetesIt's well... Christopher I publish diabetic live. Profile >> Top Diabetes Topics on Actos Glucophage Glucose meter Gestational diabetes Test Strips Type 1 Diabetes Diabetes Type 2 Diabetes Accu-Chek Januvia Lantus Metformin Ask a Question Get answers from our experts and community members. Ask a question... View all questions (2472) > Related Diabetes Topics diabetes insipidus warning signs diabetes diabetes signs symptoms diabetic ketoacidosis diabetic neuropathy what is glucose View All >> Note: All clinical content on this site is physician-reviewed, except material generated by our community members. Featuring Content From: We comply with the HONcode standard for trustworthy health information: verify here. Privacy Policy | Service Terms and Agreement | Advertising Policy | Contact Us | About Us | RSS Feed | Site Map | How to Use This Site By using this service, you accept our Terms of Use. Please read them . The consumer health information on is for informational purposes only and is not a substitute for medical advice or treatment for any medical conditions. You should promptly seek professional medical care if you have any concern about your health, and you should always consult your physician before starting a fitness regimen. Copyright © 2005-2010. 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