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The article below describes the remarkable breakthrough at the University of Alberta utilizing a procedure become known informally as the Edmonton Protocol. In an ongoing clinical trial, 7 out of 7 recipients of transplanted human islets have become insulin independent. For more information on the Edmonton Protocol, please visit the Alberta Foundation for Diabetes Research, or you may send an email directly to the AFDR.

Clinical trials using the Edmonton Protocol are scheduled to be undertaken by Dr. Bernhard Hering at the Diabetes Institute for Immunology and Transplantation at the University of Minnesota, or you may send an email directly to the DIIT.

Notice: Because of its potential therapeutic implications, this article is being released before its publication date, in accordance with the Journal's policy (Angell M and Kassirer JP. The Ingelfinger Rule revisited. N Engl J Med 1991;325:1371-2). The final version of the report will be published on July 27. (Notice posted June 6, 2000.)

ORIGINAL ARTICLE

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-free Immunosuppressive Regimen

A.M. James Shapiro, Jonathan R.T. Lakey, Edmond A. Ryan, Gregory S. Korbutt, Ellen Toth, Garth L. Warnock, Norman M. Kneteman, Ray V. Rajotte


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Copyright © 2000 by the Massachusetts Medical Society. All rights reserved.